CAS 139504-50-0 | N2′-deacetyl-N2′-(3-Mercapto-1-oxopropyl)-Maytansine

Molecular Formula: C35H48ClN3O10S
Molecular Weight: 738.29
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
Worldwide Delivery

Application

Introduction
Maytansine DM1 is a tubulin inhibitor that binds at the ends of microtubules and inhibits microtubule dynamics. Maytansine is an antibody-conjugable maytansinoid used to overcome maytansine-related systemic toxicity and enhance tumor-specific delivery.

Specification of CAS 139504-50-0 | N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine

ITEMS

SPECIFICATION

pka

9.82

Melting point

190-192℃ (decomposition)

Density

1.33 g/cm3

Storage temp.

Sealed in dry,2-8°C

Boiling point

937.1 °C

Synthesis of CAS 139504-50-0 | N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine

CAS 139504-50-0 | N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine

Conditions

With ethylenediaminetetraacetic acid; diothiothreitol In methanol; phosphate buffer; ethyl acetate for 3h; pH=7.5;

Reference

Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; (…) Blättler, Walter A.; Chari, Ravi V. J.

[Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4392 – 4408]

Hot Tags: cas 139504-50-0 | n2′-deacetyl-n2′-(3-mercapto-1-oxopropyl)-maytansine, price, quotation, discount, in stock, for sale, 1 Hydroxycyclohexyl phenyl ketone, Fosamprenavir calcium, Nano Chemicals, Biochemicals, Material Science, Inhibitors

CAS 1426953-21-0 | Thailanstatin A

CAS 146478-72-0 | FR901464

send us a message

    Home Tel Mail Inquiry