CAS 545445-44-1 | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Molecular Formula: C20H25N3O3
Molecular Weight: 355.43
EINECS: 1308068-626-2
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg

Application

Introduction
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one is an intermediate for the preparation of apixaban.

Specification of CAS 545445-44-1 | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

ITEMS

SPECIFICATION

Boiling point

625.0 °C

pka

3.25

storage temp.

Sealed in dry,2-8°C

density

1.267

Synthesis of CAS 545445-44-1 | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

CAS 545445-44-1 | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Conditions

Stage #1: 5-Chlorovaleroyl chloride; 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one With tetrabutylammomium bromide; sodium hydroxide In dichloromethane; water at 0 – 5℃; for 1h;

Stage #2: With potassium hydroxide In dichloromethane; water at 20℃; Reagent/catalyst; Solvent; Temperature;

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