CAS 663921-15-1 | α-amine-ω-propionic Acid Tetraethylene Glycol

Molecular Formula: C11H23NO6
Molecular Weight: 265.3
EINECS: 828-940-4
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg

Application

Introduction

NH2-PEG4-CH2CH2COOH is a cleavable 4-unit PEG-based ADC linker for the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.

Specification of CAS 663921-15-1 | α-amine-ω-propionic acid tetraethylene glycol

ITEMS

SPECIFICATION

Boiling point

409.6 °C

pka

4.28

Storage temp.

Sealed in dry,2-8°C

Density

1.134 g/cm3

Synthesis of CAS 663921-15-1 | α-amine-ω-propionic acid tetraethylene glycol

CAS 663921-15-1 | α-amine-ω-propionic Acid Tetraethylene Glycol

Conditions

With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 750.075 Torr; for 16h;

Reference

Béquignat, Jean-Baptiste; Boucheix, Claude; Canitrot, Damien; Chezal, Jean-Michel; Degoul, Françoise; Miot-Noirault, Elisabeth; Moreau, Emmanuel; (…) Taiariol, Ludivine; Ty, Nancy

[European Journal of Medicinal Chemistry, 2020, vol. 203, art. no. 112574]

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