CAS 877399-52-5 | Crizotinib

Molecular Formula: C21H22Cl2FN5O
Molecular Weight: 450.34
EINECS: 638-814-9
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg / 25 kg
Worldwide Delivery

Application

Introduction
Crizotinib es un inhibidor de la tirosina quinasa (TKI) de molécula pequeña que se dirige a la quinasa del linfoma anaplásico (ALK), ROS1, y a otro receptor de tirosina quinasa oncogén, MET.

Specification of CAS 877399-52-5 | Crizotinib

ITEMS

SPECIFICATION

Melting point

192 °C

Storage temp.

Room temp

Color

White to tan

Form

powder

Density

1.47 g/cm3

Boiling point

599.2 °C

pka

9.81

CAS DataBase Reference

877399-52-5

Synthesis of CAS 877399-52-5 | Crizotinib

CAS 877399-52-5 | Crizotinib

Conditions

With hydrogenchloride In 1,4-dioxane; dichloromethane; water at 0 – 20℃; for 4h; Inert atmosphere;

Reference

Cui, J. Jean; Tran-Dubé, Michelle; Shen, Hong; Nambu, Mitchell; Kung, Pei-Pei; Pairish, Mason; Jia, Lei; (…) Kania, Robert S.; Edwards, Martin P.

[Journal of Medicinal Chemistry, 2011, vol. 54, # 18, p. 6342 – 6363]

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