CAS 917389-32-3 | LeterMovir

Molecular Formula: C29H28F4N4O4
Molecular Weight: 572.55
EINECS:
Purity: 97% Min.
Package: 1 g / 5 g / 25 g / 100 g / 1 kg

Application

Introduction
Letermovir (AIC246, MK-8228) is a novel anti-CMV compound that targets the viral terminal enzyme complex and is also active against viruses that are resistant to DNA polymerase inhibitors.

Specification of CAS 917389-32-3 | LeterMovir

ITEMS

SPECIFICATION

Boiling point

706.5 °C

pka

4.00

storage temp.

Sealed in dry,Store in freezer, under -20°C

density

1.37 g/cm3

Synthesis of CAS 917389-32-3 | LeterMovir

CAS 917389-32-3 | LeterMovir

Conditions:

Stage #1: (S)-methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate (2S,3S)-2,3-bis((4-methylbenzoyl)oxy)succinate ethyl acetate With disodium hydrogenphosphate; tert-butyl methyl ether In water for 2h;

Stage #2: With sodium hydroxide In water at 60℃; for 5h; Inert atmosphere;

Reference:

Humphrey, Guy R.; Dalby, Stephen M.; Andreani, Teresa; Xiang, Bangping; Luzung, Michael R.; Song, Zhiguo Jake; Shevlin, Michael; Christensen, Melodie; Belyk, Kevin M.; Tschaen, David M.

[Organic Process Research and Development, 2016, vol. 20, # 6, p. 1097 – 1103]

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