CAS:98-92-0 | Nicotinamide

Name:Nicotinamide
CAS:98-92-0
Purity:99%
Molecular Formula:C6H6N2O
Molecular Weight:122.10
Melting Point:128-131° C (lit.)
Boiling Point:150-160 °C 

Application

Name:Nicotinamide

Synonyms:Niacinamide; Nicotinic Acid Amide; Pyridine-3-carboxylic acid amide

CAS:98-92-0

Purity:99%

Molecular Formula:C6H6N2O

Molecular Weight:122.10

Melting Point:128-131° C (lit.)

Boiling Point:150-160 °C

EINECS:202-713-4

Density:1.4 g/cm3at 20° C

Appearance:White to light yellow powder

Stability:Stable. Incompatible with strong oxidizing agents.

Solubility:Soluble in water (1000 g/l at 20° C), ethanol (100 mM), glycerol (1 g/10ml), DMSO (100 mM), methanol, butanol, chloroform, and ether (Slightly).

pKa:3.3(at 20℃)

refractive index:n20D1.47

IC50:Anandamide amidohydrolase: IC50= 3.3 µM (rat); NAD-dependent deacetylase sirtuin 2: IC50= 11 µM (human); NAD-dependent deacetylase sirtuin 3: IC50= 14 µM (human); NAD-dependent deacetylase HST2: IC50= 91 µM (Saccharomyces cerevisiae S288c)

Storage condition:2-8°C

Application:Nicotinamide(CAS:98-92-0)is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). It may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule. It is an amide derivative of vitamin B3 and a PARP inhibitor.

Reference:

Kevin J.Bitterman; Rozalyn M.Anderson;Haim Y.Cohen; Magda Latorre-Esteves; David A.Sinclair. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of Yeast Sir2 and Human SIRT1.The Journal of Biological Chemistry.2002,277,(47),45099-45107

Rozalyn M.Anderson; Kevin J.Bitterman; Jason G.Wood; Oliver Medvedik; David A.Sinclair. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.Letters to Nature.2003,423,181-185

Packaging & Delivery

Package:100g/250g/500g/bulk package

Transportation:by FeDex or by ocean shippingorclients requirement

Delivery Detail:Within 3-5 days after full payment

Flexible payment terms:support T/T, Paypal , Credit Card

CAS:98-92-0 | Nicotinamide


Hot Tags: cas:98-92-0 | nicotinamide, price, quotation, discount, in stock, for sale, Metal Catalysts, 2 4 6 Tri tert butylphenol, Fosamprenavir calcium, Sodium thiosulfate pentahydrate, MOF COF Ligands, L Tyrosine

CAS:2682-20-4 | 2-Methyl-4-isothiazolin-3-one

CAS:9004-82-4 | Sodium Lauryl Polyoxyethylene Ether Sulfate

send us a message

    Home Tel Mail Inquiry